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KMID : 1123920030170030787
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Korean Journal of Oriental Physiology and Pathology
2003 Volume.17 No. 3 p.787 ~ p.790
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Effect of Alii Macrostemi Bulbus on Cultured Mouse Osteoblasts Damaged by Reactive Oxygen Species
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Son Il-Hong
Yang Hyun-Woong
Lee Jai-Kyoo
Lee Kang-Chang
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Abstract
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It has been demonstrated that oxidative stress of reactive oxygen species(ROS) may be a causative factor in the pathogenesis of bony disorder. The purpose of this study was to evaluate the oxidative stress of glucose oxidase(GO) in the cultured mouse osteoblasts and the protective effect of Alii Macrostemi Bulbus(AMB) on ROS-induced osteotoxicity. Toxic effect of GO and protective effect of AMB were carried out by colorimetric assay. 20mU/mi GO decreased cell viability dose-dependently, and AMB increased cell viability against GO-induced cytotoxicity in these cultures. From above the results. GO has toxic effect, and AMB is very effective on GO-induced osteotoxicity in cultured osteoblasts of neonatal mouse.
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KEYWORD
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Cultured osteoblast, Alii Macrostemi Bulbus, Glucose oxidase
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